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pentobarbital will lessen the extent or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers reduces plasma concentration of abemaciclib and its metabolites.If your dose of your concomitant CYP3A4 inducer can not be minimized